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Monday, January 20, 2020
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Most Children Don't Receive Measles Vaccine Before Traveling Abroad

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In this Issue

•  IVIG/Albumin Supply Index
•  Open Market Pricing
•  New Products from FFF
•  Current Medicare
•  Resources
•  Subscribe to IG Living and BioSupply Trends Quarterly

A study shows nearly 60 percent of children are not vaccinated with the measles, mumps and rubella vaccine before traveling abroad. And, while children make up only 10 percent of U.S. international travelers, they account for nearly half of imported measles cases. read more ]

Recombinant IVIG Technology Could Reduce Global Shortage

With a global shortage of immune globulin (IG), GigaGen is developing a recombinant intravenous IG (IVIG) product that could prevent future shortages. The company's recombinant IVIG therapy has been validated in mouse models and is being advanced in collaboration with other leaders, including Grifols. read more ]

Stewardship Program Improves IVIG Prescribing

A multidisciplinary team of clinical pharmacists, physicians, nurses, informaticians and IT specialists developed a stewardship program to improve and standardize intravenous immune globulin (IVIG) dosing in their healthcare organization, and found institution-specific ordering patterns may facilitate more efficiency and effective prescribing and optimized drug dosing. read more ]

Industry News

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From CSL Behring

CSL Behring's Hizentra (subcutaneous immune globulin [human] 20% liquid) has received orphan drug exclusivity from the U.S. Food and Drug Administration for the treatment of adult patients with chronic inflammatory demyelinating polyneuropathy as maintenance therapy to prevent relapse of neuromuscular disability and impairment.

From Novartis

Novartis' multiple sclerosis drug Gilenya (fingolimod) may have three new U.S. Food and Drug Administration (FDA)-approved generic competitors. FDA approved generic fingolimod applications from HEC Pharm Co. Limited, Biocon Limited and Sun Pharmaceutical Industries Limited. However, Novartis is currently in court fighting to extend its exclusivity for the drug, so until patent issues are sorted out, no generic versions of Gilenya may enter the U.S. market.  [ read more ]

From Argenx

Phase II study results show efgartigimod, a neonatal Fc receptor antagonist, was well-tolerated and effective in patients with primary immune thrombocytopenia, a bleeding disorder characterized by a low platelet count that is difficult to treat.  [ read more ]

IVIG & Albumin Supply Index

IVIG and Albumin Days On Hand
  button to click to see FEIBA full prescribing information  

What's New at FFF


ACETAZOLAMIDE (for injection, USP), an inhibitor of the enzyme carbonic anhydrase, is indicated for adjunctive treatment of edema due to congestive heart failure; drug-induced edema; centrencephalic epilepsies (petit mal, unlocalized seizures); chronic simple (open-angle) glaucoma, secondary glaucoma, and preoperatively in acute angle-closure glaucoma where delay of surgery is desired to lower intraocular pressure. It is supplied as lyophilized powder in 500 mg vials.

For more information about ACETAZOLAMIDE, log in to


ACYCLOVIR (sodium injection) is indicated for the treatment of initial and recurrent mucosal and cutaneous herpes simplex (HSV-1 and HSV-2) infections and varicella-zoster (shingles) infections in immunocompromised adults and children. It is also indicated for severe initial episodes of herpes simplex infections in patients who may not be immunocompromised. It is available in two sizes: a 10 mL single-dose vial containing acyclovir sodium equivalent to 500 mg acyclovir, packaged in trays of 10 vials; and a 20 mL single-dose vial containing acyclovir sodium equivalent to 1 gram of acyclovir, packaged in trays of 10 vials.

For more information about ACYCLOVIR, log in to


ATROPINE SULFATE (injection) is indicated for temporary blockade of severe or life-threatening muscarinic effects such as an antisialagogue, an antivagal agent, an antidote for organophosphorus, carbamate or muscarinic mushroom poisoning; and to treat symptomatic bradycardia. It is a nonpyrogenic, isotonic, clear solution supplied in a multiple-dose glass vial.

For more information about ATROPINE SULFATE, log in to


CALCIUM CHLORIDE (10% injection, USP) is indicated for the treatment of hypocalcemia in patients requiring a prompt increase in plasma calcium levels. It is supplied in a 10 mL single-dose container.

For more information about CALCIUM CHLORIDE, log in to


CORVERT (injection) is indicated for the rapid conversion of atrial fibrillation or atrial flutter of recent onset to sinus rhythm. It is supplied as an acetate-buffered isotonic solution in a single-dose 10 mL vial (1 mg /10 mL).

For more information about CORVERT, log in to


DESTROSE 50% (injection) is indicated in the treatment of insulin hypoglycemia (hyperinsulinemia or insulin shock) to restore blood glucose levels. It is also indicated, after dilution, for intravenous infusion as a source of carbohydrate calories in patients whose oral intake is restricted or inadequate to maintain nutritional requirements. It is supplied in a 50 mL (500 mg/m) single-dose prefilled syringe.

For more information about DEXTROSE 50%, log in to


EPINEPHRINE (injection, USP) is indicated for the treatment and prophylaxis of cardiac arrest due to various causes in the absence of ventricular fibrillation and attacks of transitory atrioventricular (AV) heart block with syncopal seizures (Stokes-Adams syndrome), but it is not used in cardiac failure or in hemorrhagic, traumatic or cardiogenic shock. Epinephrine may be used to stimulate the heart in syncope due to complete heart block or carotid sinus hypersensitivity. Epinephrine is also used for resuscitation in cardiac arrest following anesthetic accidents. It is supplied in a 10-carton package of single-use 0.1 mg/mL packages containing a Luer-Jet Luer-Lock.

For more information about EPINEPHRINE, log in to


LIDOCAINE HCL (injection, USP) is indicated for production of local or regional anesthesia by infiltration techniques such as percutaneous injection by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks, when the accepted procedures for these techniques as described in standard textbooks are observed. It is supplied in 1% (50 mg/5 mL) (10 mg/mL) 5 mL single-dose vials packaged in 25s and 2% (100 mg/5 mL) (20 mg/mL) 5 mL single-dose vials packaged in 25s.

For more information about LIDOCAINE HCL, log in to


PHYTONADIONE (VIT K, intramuscular or subcutaneous injection) is indicated in the following coagulation disorders due to faulty formation of factors II, Vll, IX and X when caused by vitamin K deficiency or interference with vitamin K activity: anticoagulant-induced prothrombin deficiency caused by coumarin or indanedione derivatives; prophylaxis and therapy of hemorrhagic disease of the newborn; hypoprothrombinemia due to antibacterial therapy; hypoprothrombinemia secondary to factors limiting absorption or synthesis of vitamin K; and other drug-induced hypoprothrombinemia where it is definitely shown that the result is due to interference with vitamin K metabolism. It is supplied in packages of 10 single-use 1 mg 0.5 mL vials and a SAF-T-Jet vial injector with a 27-gauge ½-inch needle.

For more information about PHYTONADIONE (VIT K), log in to


SODIUM BICARBONATE (injection, USP) is indicated in the treatment of metabolic acidosis that may occur in severe renal diseases, uncontrolled diabetes, circulatory insufficiency due to shock or severe dehydration, extracorporeal circulation of blood, cardiac arrest and severe primary lactic acidosis. It is further indicated in the treatment of certain drug intoxications, including barbiturates (where dissociation of the barbiturate-protein complex is desired), in poisoning by salicylates or methyl alcohol and in hemolytic reactions requiring alkalinization of the urine to diminish nephrotoxicity of hemoglobin and its breakdown products. It is also indicated in severe diarrhea that is often accompanied by a significant loss of bicarbonate. It is supplied in 50 mL single-dose packages containing a Luer-Jet Luer-Lock prefilled syringe. 10 individual cartons are shrink-wrapped as a group of 10 cartons.

For more information about SODIUM BICARBONATE, log in to


VINCRISTINE (sulfate injection, USP) is indicated in acute leukemia. It has also been shown to be useful in combination with other oncolytic agents in Hodgkin's disease, non–Hodgkin's malignant lymphomas, rhabdomyosarcoma, neuroblastoma and Wilms' tumor. It is supplied 1 mg/1 mL (single-dose) flip–top vials and 2 mg/2 mL (single-dose) flip–top vials.

For more information about VINCRISTINE, log in to


ZIRABEV (injection) is indicated for the treatment of metastatic colorectal cancer in combination with intravenous fluorouracil-based chemotherapy for first- or second-line treatment, and metastatic colorectal cancer in combination with fluoropyrimidine-irinotecan- or fluoropyrimidine-oxaliplatin-based chemotherapy for second-line treatment in patients who have progressed on a first-line bevacizumab product-containing regimen. It is supplied as a sterile solution for intravenous infusion supplied in a carton containing one single-dose vial in the following strengths: 100 mg/4 mL (25 mg/mL) and 400 mg/16 mL (25 mg/mL).

For more information about ZIRABEV, log in to

These products can be ordered from FFF Enterprise's BioSupply Online Ordering System or by calling
Wow! Customer Care at (800) 843-7477.

Current Medicare IVIG / SCIG Rates

Rates per gram are effective Jan. 1, 2020, through March 31, 2020.

Calculate your current medicare IVIG/SCIG Rates
Product J Codes ASP + 6%
(before sequester)
ASP + 4.3%*
(after sequester)
Flebogamma J1572 $71.55 $70.40
Gammagard S/D J1566 $126.38 $124.35
Gammaplex J1557 $92.45 $90.97
Octagam J1568 $76.43 $75.21
Privigen J1459 $81.69 $80.38
CUVITRU J1555 $140.10 $137.85
Hizentra J1559 $104.95 $103.27
HyQvia J1575 $146.35 $144.00
Gammagard Liquid J1569 $79.84 $78.56
Gammaked J1561 $80.69 $79.40
Gamunex-C J1561 $80.69 $79.40

*Reflects 2% sequestration reduction applied to 80% Medicare payment portion as required under Budget Control Act of 2011.

Log in to BioSupply for Immune Globulin Products


FFF customers may order the following complementary resources to help you with your practice:

Seasonal Flu Poster flu myths and facts brochure
immune globulin reference charts
•  IG Immune Globulin (Human)
•  Hyperimmune Globulins
•  Anti-Inhibitor, Factor VIIa & IX
•  Factor VIII & von Willebrand Factor
•  Seasonal Influenza Vaccine

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